Cotecchia S, De Blasi A
Life Sci. 1984 Dec 3;35(23):2359-64. doi: 10.1016/0024-3205(84)90528-9.
A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological concentrations. In saturation experiments hydrocortisone (10(-6)M) significantly raised beta-adrenoceptor Bmax and KD. Intact living lymphocytes seem to be a useful model for further investigation in man of the regulation of beta-adrenoceptors by glucocorticoids in physiological conditions.
在给予糖皮质激素后，已在不同的人类和动物组织中观察到β-肾上腺素能受体结合的改变。在本研究中，我们观察到，在生理和药理浓度下，氢化可的松在体外可增加用³H-二氢阿普洛尔标记的人完整淋巴细胞β-肾上腺素能受体。在饱和实验中，氢化可的松（10⁻⁶M）显著提高了β-肾上腺素能受体的Bmax和KD。完整的活淋巴细胞似乎是在生理条件下进一步研究人类糖皮质激素对β-肾上腺素能受体调节的有用模型。
