Luini A, Goldberg O, Teichberg V I
Neurosci Lett. 1984 Aug 31;49(3):325-30. doi: 10.1016/0304-3940(84)90310-0.
The depolarization of brain slices by high K+ concentrations in the presence of Ca2+ ions leads to the release from nerve terminals of endogenous excitatory neurotransmitters that interact with subsynaptic receptors controlling the neuronal membrane permeability to Na+ ions. This interaction has been studied by following the K+-evoked Ca2+-dependent 22Na+ efflux from 22Na+-preloaded slices from the cortex, striatum, hippocampus, cerebellum, substantia nigra and hypothalamus of the rat. The results indicate that the so-called N-methyl-D-aspartate receptor mediates the bulk of the excitatory transactions in the cortex and striatum whereas a subsynaptic glutamate receptor may mediate those in the hippocampus and cerebellum.
在存在钙离子的情况下，高钾离子浓度使脑片去极化，导致内源性兴奋性神经递质从神经末梢释放，这些神经递质与控制神经元膜对钠离子通透性的突触下受体相互作用。通过追踪大鼠皮质、纹状体、海马体、小脑、黑质和下丘脑预先装载了22Na+的脑片中钾离子诱发的钙离子依赖性22Na+外流，对这种相互作用进行了研究。结果表明，所谓的N-甲基-D-天冬氨酸受体介导了皮质和纹状体中的大部分兴奋性传递，而一种突触下谷氨酸受体可能介导海马体和小脑中的兴奋性传递。
