Bovier P, Broekkamp C L, Lloyd K G
Pharmacol Biochem Behav. 1984 Sep;21(3):353-6. doi: 10.1016/s0091-3057(84)80094-5.
In a procedure to measure the escape latency and threshold for aversive electrical stimulation of the Peri-Aqueductal Gray (PAG) the effect of ethyl alcohol was tested in order to validate aversive PAG stimulation further as a model for testing potential anxiolytics. Doses of 0.2-1.6 g/kg were given orally in an ascending sequence and were found to increase escape latency and threshold. A second dose of 0.8 g/kg had no effect, suggesting development of tolerance. Spontaneous activity in the test environment was not changed by alcohol. These results indicate specific effects of alcohol on aversive stimulation and reinforce the suggestion to use this phenomenon as a model for human anxiety.
在一项测量中脑导水管周围灰质（PAG）厌恶电刺激的逃避潜伏期和阈值的实验中，测试了乙醇的作用，以进一步验证厌恶PAG刺激作为测试潜在抗焦虑药物模型的有效性。按递增顺序口服给予0.2 - 1.6 g/kg的剂量，发现这些剂量会增加逃避潜伏期和阈值。第二剂0.8 g/kg没有效果，表明产生了耐受性。测试环境中的自发活动未因酒精而改变。这些结果表明酒精对厌恶刺激有特定作用，并支持将此现象用作人类焦虑模型的建议。
