Berezak A, Weber M, Hansmann J, Tulasne P A, Laporte B, Ould Ouali A
Ann Fr Anesth Reanim. 1984;3(5):383-4. doi: 10.1016/s0750-7658(84)80078-7.
During the last years, there have been more and more observations of physical dependence on the benzodiazepines. This paper emphasizes the seriousness of this syndrome, its similarity with delirium tremens and its optimal treatment by high doses of benzodiazepines. This article shows also the misuse of drugs lowering the epileptogenic threshold and suggests in replacement the peranaesthesic administration of benzodiazepines or barbiturates. Finally the treatment should be started with a gradual and slow withdrawal so as to avoid undesirable neurological signs.
在过去几年中，对苯二氮䓬类药物产生身体依赖的观察越来越多。本文强调了这种综合征的严重性、它与震颤谵妄的相似性以及用高剂量苯二氮䓬类药物进行最佳治疗。本文还指出了降低癫痫发作阈值药物的滥用情况，并建议改用苯二氮䓬类药物或巴比妥类药物进行麻醉前给药。最后，治疗应从逐渐缓慢撤药开始，以避免出现不良神经症状。
