人淋巴细胞的二肽基肽酶IV。T淋巴细胞中甘氨酰脯氨酸对硝基苯胺特异性水解的证据。
Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylproline p-nitroanilide in T-lymphocytes.
作者信息
Schön E, Demuth H U, Barth A, Ansorge S
出版信息
Biochem J. 1984 Oct 1;223(1):255-8. doi: 10.1042/bj2230255.
Abstract
Glycylproline p-nitroanilide is hydrolysed in lymphocytes from human blood exclusively by dipeptidyl peptidase IV. This was demonstrated by specific inhibition with N-alanylprolyl-O-(4-nitrobenzoyl)hydroxylamine and di-isopropyl phosphorofluoridate and by studying the membrane localization of dipeptidyl peptidase IV and determining specific dipeptidyl peptidase II activity. Additional evidence that dipeptidyl peptidase IV is a marker for T-lymphocytes, obtained from determinations of biochemical activity on intact lymphocyte preparations and correlation studies with other T-cell markers, is also presented.
摘要
甘氨酰脯氨酸对硝基苯胺仅在人血淋巴细胞中由二肽基肽酶IV水解。这通过用N-丙氨酰脯氨酰-O-(4-硝基苯甲酰基)羟胺和二异丙基氟磷酸酯进行特异性抑制，以及研究二肽基肽酶IV的膜定位和测定特异性二肽基肽酶II活性得以证明。还提供了额外的证据，表明二肽基肽酶IV是T淋巴细胞的标志物，这是通过对完整淋巴细胞制剂进行生化活性测定以及与其他T细胞标志物进行相关性研究得出的。
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