Walter R, Simmons W H, Yoshimoto T
Mol Cell Biochem. 1980 Apr 18;30(2):111-27. doi: 10.1007/BF00227927.
Peptidases which are specific for proline residues have been described and include endopeptidases (post-proline cleaving enzyme and proline specific endopeptidase), N-terminal exopeptidases (post-proline dipeptidyl aminopeptidase, proline iminopeptidase, aminopeptidase P), C-terminal exopeptidases (prolylcarboxypeptidase, and carboxypeptidase P) and dipeptidases (prolyl dipeptidase and proline dipeptidase). The properties, distinguishing charcteristics, and possible significance of these proline specific endo- and exopeptidases are discussed. In addition, reference is made to a series of enzymes which can hydrolyze proline containing peptide bonds, but which are not specific for proline.
已经描述了对脯氨酸残基具有特异性的肽酶，包括内肽酶（脯氨酸后切割酶和脯氨酸特异性内肽酶）、N端外肽酶（脯氨酸后二肽基氨基肽酶、脯氨酸亚氨基肽酶、氨基肽酶P）、C端外肽酶（脯氨酰羧肽酶和羧肽酶P）以及二肽酶（脯氨酰二肽酶和脯氨酸二肽酶）。讨论了这些脯氨酸特异性内肽酶和外肽酶的性质、区别特征以及可能的意义。此外，还提及了一系列能够水解含脯氨酸肽键但对脯氨酸无特异性的酶。
