Hege H G, Lietz H, Weymann J
Arzneimittelforschung. 1984;34(8):843-9.
The synthesis of 14C-propafenone and 2H-propafenone (propafenone: 2-(2'-hydroxy-3'-propylamino-propoxy)-omega-phenyl-propiophenone hydrochloride) and some reference compounds is described. The thin-layer chromatographic, high-performance liquid and gas chromatographic properties of the substances are described. Propafenone and the reference substances were studied by mass spectrometry and compared with each other, with respect to structural elucidation of the metabolites. The chromatographic and mass spectrometric data (key ions) enables the metabolites of propafenone to be identified in biological material.
描述了14C-普罗帕酮和2H-普罗帕酮（普罗帕酮：2-(2'-羟基-3'-丙基氨基丙氧基)-ω-苯基苯丙酮盐酸盐）及一些参考化合物的合成。阐述了这些物质的薄层色谱、高效液相色谱和气相色谱性质。通过质谱对普罗帕酮和参考物质进行了研究，并就代谢物的结构解析相互进行了比较。色谱和质谱数据（关键离子）能够鉴定生物材料中普罗帕酮的代谢物。
