Meier-Tackmann D, Agarwal D P, Goedde H W
Alcohol Alcohol. 1984;19(1):7-12.
Determination of plasma alcohol dehydrogenase (ADH) in patients with alcohol-related disorders may be a valuable diagnostic and prognostic parameter. By using a sensitive spectrophotometric method we have measured the plasma ADH activity in chronic alcoholics, non-alcoholic psychiatric patients and healthy blood donors from Germany. Serum alanine aminotransferase (GPT) and serum gamma-glutamyltransferase (gamma-GT) values were included for the comparative study to assess the extent of hepatic complications. The results indicate that plasma ADH activity in alcoholics and non-alcoholic psychiatric patients was significantly raised only when higher GPT and gamma-GT values were observed, which may hint at a generalized liver damage. It is suggested that plasma ADH determination alone is not useful as a diagnostic marker of alcoholism but could be of value when measured in combination with other biochemical parameters.
测定酒精相关疾病患者的血浆乙醇脱氢酶（ADH）可能是一个有价值的诊断和预后参数。我们采用一种灵敏的分光光度法，测定了来自德国的慢性酗酒者、非酒精性精神疾病患者和健康献血者的血浆ADH活性。纳入血清丙氨酸转氨酶（GPT）和血清γ-谷氨酰转移酶（γ-GT）值进行比较研究，以评估肝脏并发症的程度。结果表明，仅当观察到较高的GPT和γ-GT值时，酗酒者和非酒精性精神疾病患者的血浆ADH活性才会显著升高，这可能暗示存在广泛性肝损伤。建议单独测定血浆ADH作为酒精中毒的诊断标志物并无用处，但与其他生化参数联合测定时可能有价值。
