Dommisse C S, Schulz S C, Narasimhachari N, Blackard W G, Hamer R M
Biol Psychiatry. 1984 Sep;19(9):1305-15.
Dextroamphetamine 30 mg and placebo were administered by mouth in a double-blind randomized cross-over trial to ten subjects. Behavior was assessed and blood samples analyzed for growth hormone (GH), prolactin (PRL), homovanillic acid (HVA), and amphetamine. There was a statistically significant increase in well-being following d-amphetamine as compared to baseline and placebo on both the Amphetamine Interview Rating Scale and the Hopkins Mood Scale. No subject became psychotic. There was a statistically significant increase in GH from baseline to peak following d-amphetamine ingestion. When compared to placebo, the increase in GH was invariable and statistically significant for the 90-min sampling. PRL decreased from baseline following both d-amphetamine and placebo and there was no significant drug-placebo difference. Serum HVA was measured at baseline and 120 min, for eight subjects. Six subjects had an increase in HVA following d-amphetamine but there was no significant drug effect.
在一项双盲随机交叉试验中，对10名受试者口服30毫克右旋苯丙胺和安慰剂。评估行为表现，并分析血样中的生长激素（GH）、催乳素（PRL）、高香草酸（HVA）和苯丙胺含量。与基线水平和安慰剂相比，在苯丙胺访谈评定量表和霍普金斯情绪量表上，右旋苯丙胺给药后幸福感有统计学意义的显著增加。没有受试者出现精神病症状。右旋苯丙胺摄入后，从基线到峰值，GH有统计学意义的显著增加。与安慰剂相比，在90分钟采样时，GH的增加是恒定的且具有统计学意义。服用右旋苯丙胺和安慰剂后，PRL均从基线水平下降，且药物与安慰剂之间无显著差异。对8名受试者在基线和120分钟时测量血清HVA。6名受试者在服用右旋苯丙胺后HVA增加，但药物效果不显著。
