Richelson E
Geriatrics. 1984 Dec;39(12):30-6, 39-42.
Alcohol can increase blood levels of diazepam, and probably of other benzodiazepines. Alcohol also potentiates the CNS-depressant effects of these drugs. Before adding a psychotropic drug in older patients, discontinue as many drugs as possible. Prescribe smaller doses and follow cardiovascular status. Determine serum levels when in doubt, especially with tricyclic antidepressants.
酒精会提高地西泮的血药浓度,可能也会提高其他苯二氮䓬类药物的血药浓度。酒精还会增强这些药物的中枢神经系统抑制作用。在老年患者中加用精神药物之前,应尽可能停用多种药物。开具较小剂量并监测心血管状况。如有疑问,尤其是对于三环类抗抑郁药,应测定血清药物浓度。