Stephen P J, Williamson J
Lancet. 1984 Nov 10;2(8411):1082-3. doi: 10.1016/s0140-6736(84)91516-2.
Of 95 new cases of parkinsonism referred to a department of geriatric medicine, 48 (51%) were associated with prescribed drugs. Clinical features in drug-induced and idiopathic cases were very similar, including the proportion with typical tremor. 25% of patients with drug-induced parkinsonism (DIP) could not walk when first seen and 45% required hospital admission (for a median stay of 23 days, range 5-101). The clinical features of DIP resolved permanently in two-thirds of cases in a mean of 7 weeks but with a range of 1 to 36 weeks. 5 cases of DIP initially resolved but idiopathic parkinsonism developed after an interval of 3 to 18 months. Perhaps some old people have low striatal dopamine levels and a small neuroleptic effect tips them into overt parkinsonism or unmasks latent idiopathic disease. The commonest offending drug was prochlorperazine (21 cases). In no case did this drug seem to be indicated.
在转至老年医学科的95例帕金森综合征新病例中，48例（51%）与处方药有关。药物性和特发性病例的临床特征非常相似，包括典型震颤的比例。25%的药物性帕金森综合征（DIP）患者初诊时无法行走，45%需要住院治疗（中位住院时间为23天，范围为5 - 101天）。三分之二的DIP病例临床特征在平均7周内永久缓解，但范围为1至36周。5例DIP最初缓解，但在3至18个月的间隔后发展为特发性帕金森病。也许一些老年人纹状体多巴胺水平较低，较小的抗精神病药物效应会使他们发展为明显的帕金森病或使潜在的特发性疾病显现出来。最常引起问题的药物是氯丙嗪（21例）。在任何情况下，这种药物似乎都没有指征。
