药物性帕金森综合征早期体征的研究。
A study of the early signs of drug induced parkinsonism.
作者信息
Arblaster L A, Lakie M, Mutch W J, Semple M
机构信息
Applied Physiology Research Unit, School of Sport and Exercise Sciences, University of Birmingham, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1993 Mar;56(3):301-3. doi: 10.1136/jnnp.56.3.301.
Postural tremor was recorded from psychiatric patients who had been treated with phenothiazine or butyrophenone neuroleptic drugs. None of the patients had previously been diagnosed as having extrapyramidal dysfunction. A significant number of these patients had abnormally low tremor frequencies. Low frequency tremors are often associated with Parkinson's disease (PD) so that some of these patients may have early signs of drug induced Parkinsonism (DIP). The results indicate that DIP is not necessarily characterised by a bilateral slow frequency tremor, but may initially be similar to idiopathic PD, even though its cause and prognosis are different.
对曾接受吩噻嗪或丁酰苯类抗精神病药物治疗的精神科患者进行了姿势性震颤记录。这些患者之前均未被诊断为锥体外系功能障碍。其中相当一部分患者的震颤频率异常低。低频震颤常与帕金森病（PD）相关，因此这些患者中的一些可能有药物性帕金森综合征（DIP）的早期迹象。结果表明，DIP不一定表现为双侧低频震颤，但其初始表现可能与特发性PD相似，尽管其病因和预后不同。
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