Thompson C H, Lichtenstein M, Stacker S A, Leyden M J, Salehi N, Andrews J T, McKenzie I F
Lancet. 1984 Dec 1;2(8414):1245-7. doi: 10.1016/s0140-6736(84)92798-3.
A radiolabelled monoclonal antibody that reacts with human breast cancer was injected into the web space of each hand in eight women with breast cancer, and the axillae were scanned 16-24 h later. Scans were positive in seven axillae with palpable lymph nodes and in two axillae with impalpable lymph nodes (metastases later confirmed by needle aspiration). The scan was negative in one axilla with a palpable mass, and here no tumour cells were obtained on needle aspiration. In a man with axillary lymphoma, no specific binding of antibody was observed. This technique could lead to earlier and more precise diagnosis of lymph node metastasis in patients with breast cancer.
将一种能与人乳腺癌发生反应的放射性标记单克隆抗体注射到8名乳腺癌女性患者每只手的指蹼间隙，16 - 24小时后对腋窝进行扫描。7个可触及淋巴结的腋窝扫描呈阳性，2个不可触及淋巴结的腋窝扫描也呈阳性（后来经针吸活检证实有转移）。1个可触及肿块的腋窝扫描为阴性，针吸活检未发现肿瘤细胞。在1例腋窝淋巴瘤男性患者中，未观察到抗体的特异性结合。该技术可使乳腺癌患者淋巴结转移的诊断更早、更精确。
