Brown R G, Marsden C D
Lancet. 1984 Dec 1;2(8414):1262-5. doi: 10.1016/s0140-6736(84)92807-1.
Current estimates suggest that about one in three patients with Parkinson's disease will become demented. Critical review of the studies on which this conclusion is based indicate that this figure is inflated. Errors in separating idiopathic Parkinson's disease from other causes of the akinetic-rigid syndrome, in differentiating dementia from confusional states, depression, and even normal ageing, and in defining and assessing dementia itself may have led to overestimation of the prevalence. A more conservative estimate is that one in five patients with Parkinson's disease is demented, but this assertion needs to be put to rigorous examination.
目前的估计表明,约三分之一的帕金森病患者会出现痴呆。对得出这一结论的研究进行严格审查后发现,这一数字被夸大了。在将特发性帕金森病与运动不能-强直综合征的其他病因区分开来、将痴呆与意识模糊状态、抑郁症甚至正常衰老区分开来,以及在定义和评估痴呆本身时出现的错误,可能导致了患病率的高估。一个更保守的估计是,五分之一的帕金森病患者患有痴呆,但这一论断需要经过严格检验。