Oertel W H
Klinikum Grosshadern, Ludwig-Maximilians-Universität, Munich, Fed. Rep. of Germany.
Arzneimittelforschung. 1995 Mar;45(3A):386-9.
Parkinson's disease is a neurodegenerative progressive disorder with a prevalence of 1% in the population above 65 years of age. Thus, Parkinson's disease (PD) is 5 times less common than senile dementia of the Alzheimer type (SDAT). This article summarizes an epidemoliogical door to door survey on the prevalence of Parkinson syndromes in two German villages. It reviews the present possibilities to diagnose Parkinson's disease clinically and with pharmacological and imaging techniques. As 10-30% of Parkinson's disease patients become demented in the course of the disease, the question is addressed, how Parkinson's disease relates to SDAT. In addition, it is discussed, whether a global or focal deficit of cognitive function is present in Parkinson's disease. Finally, a new imaging technique based on the visualisation of dopamine uptake sites in the striatum by single photon computed emission tomography is presented. This technique may allow to diagnose Parkinson's disease in the very early clinical and may be even preclinical phase.
帕金森病是一种神经退行性进展性疾病，在65岁以上人群中的患病率为1%。因此，帕金森病（PD）的发病率比阿尔茨海默型老年痴呆症（SDAT）低5倍。本文总结了对德国两个村庄帕金森综合征患病率进行的逐户流行病学调查。它回顾了目前临床上以及通过药理学和成像技术诊断帕金森病的可能性。由于10%至30%的帕金森病患者在病程中会出现痴呆，因此探讨了帕金森病与SDAT的关系。此外，还讨论了帕金森病是否存在整体或局部认知功能缺陷。最后，介绍了一种基于单光子计算机发射断层扫描可视化纹状体中多巴胺摄取位点的新成像技术。这种技术可能有助于在临床早期甚至临床前期诊断帕金森病。
