阿尔茨海默病与帕金森病痴呆之间的神经心理学和精神差异。
Neuropsychological and psychiatric differences between Alzheimer's disease and Parkinson's disease with dementia.
作者信息
Starkstein S E, Sabe L, Petracca G, Chemerinski E, Kuzis G, Merello M, Leiguarda R
机构信息
Department of Behavioral Neurology, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
出版信息
J Neurol Neurosurg Psychiatry. 1996 Oct;61(4):381-7. doi: 10.1136/jnnp.61.4.381.
OBJECTIVE
To examine neuropsychological and neuropsychiatric differences between patients with probable Alzheimer's disease and patients with Parkinson's disease and dementia.
METHODS
Thirty three patients with probable Alzheimer's disease and 33 patients with Parkinson's disease and dementia were matched for age, sex, and mini mental state examination scores and given a battery of neuropsychological and neuropsychiatric tests.
RESULTS
Patients with Parkinson's disease with dementia had a significantly higher prevalence of major depression than patients with Alzheimer's disease; patients with Alzheimer's disease showed more severe anosognosia and disinhibition than patients with Parkinson's disease. Whereas no significant between group differences were found on tests of memory and language, demented patients with Parkinson's disease had a significantly greater impairment on a test of visual reasoning than patients with Alzheimer's disease.
CONCLUSION
There were significant psychiatric differences between patients with Alzheimer's disease and demented patients with Parkinson's disease, but neuropsychological differences were restricted to a single cognitive domain.
目的
研究可能患有阿尔茨海默病的患者与患有帕金森病及痴呆症的患者之间的神经心理学和神经精神学差异。
方法
选取33例可能患有阿尔茨海默病的患者和33例患有帕金森病及痴呆症的患者，按照年龄、性别和简易精神状态检查表评分进行匹配，并对他们进行一系列神经心理学和神经精神学测试。
结果
患有帕金森病及痴呆症的患者中重度抑郁症的患病率显著高于患有阿尔茨海默病的患者；患有阿尔茨海默病的患者比患有帕金森病的患者表现出更严重的疾病感缺失和脱抑制。虽然在记忆和语言测试中未发现组间有显著差异，但患有帕金森病的痴呆患者在视觉推理测试中的损伤明显大于患有阿尔茨海默病的患者。
结论
患有阿尔茨海默病的患者与患有帕金森病的痴呆患者之间存在显著的精神差异，但神经心理学差异仅限于单一认知领域。
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