Iarygin N E, Shilkina N P, Romanov V A, Panchenko S V
Arkh Patol. 1984;46(10):26-31.
Clinical, immunological, morphological and immunomorphological data are provided showing the presence of induced (therapeutic) pathomorphosis in Kussmaul-Meier's disease. The conclusion is drawn that at present periarteritis nodosa is characterized by a chronic course with a domination of productive (immunocellular) vasculitis over necrotic (immunocomplex) vasculitis. It is shown that modern polychemotherapy of Kussmaul-Meier's disease favours mainly the correction of humoral immunity alterations while the pathology of cell immunity is retained. It is noted that long interruptions in therapy result in a reversion of the clinical-anatomical manifestations of periarteritis nodosa.
提供了临床、免疫学、形态学和免疫形态学数据，表明在库斯莫尔-迈尔病中存在诱导性（治疗性）病理形态变化。得出的结论是，目前结节性多动脉炎的特点是病程慢性，以增生性（免疫细胞性）血管炎为主，坏死性（免疫复合物性）血管炎次之。结果表明，库斯莫尔-迈尔病的现代联合化疗主要有利于纠正体液免疫改变，而细胞免疫病理依然存在。值得注意的是，治疗的长期中断会导致结节性多动脉炎临床解剖表现的逆转。
