Beji M, Khedher I, Ayadi N, Azouzi H, Hamza M
Service de Médecine interne, Hôpital Militaire de Gabés.
Tunis Med. 1999 Nov;77(11):585-8.
The cases of vasculitis associated to malignant tumour are uncommon, their course which is often parallel suggests a direct link between them. We report the observation of periarteritis nodosa associated with a lung cancer discovered in the following of vasculitis; whereas the course is favorable in 83 years old man without particular history. The frequency of neoplasia with vasculitis is estimated between 3 and 8%, and periarteritis nodosa can't be a paraneoplastic syndrome. Lung and colic tumours are the most frequent reported of the solid tumours. The delay of appearance of vasculitis varies from 25 months before to 9 months after cancer diagnosis. There are many factors, either some treatment, the neoantigens involve the formation of immune complexes, lymphokines and some vasoactive substances.
与恶性肿瘤相关的血管炎病例并不常见，它们的病程往往平行，提示两者之间存在直接联系。我们报告了1例在血管炎之后发现的与肺癌相关的结节性多动脉炎病例；该83岁男性患者无特殊病史，病程呈良性。血管炎合并肿瘤的发生率估计在3%至8%之间，结节性多动脉炎不能被视为副肿瘤综合征。肺癌和结肠癌是最常报告的实体肿瘤。血管炎出现的时间从癌症诊断前25个月到诊断后9个月不等。有许多因素，包括一些治疗、新抗原参与免疫复合物、淋巴因子和一些血管活性物质的形成。
