Kozak W, Valzelli L, Garattini S
Eur J Pharmacol. 1984 Oct 15;105(3-4):323-6. doi: 10.1016/0014-2999(84)90625-3.
The evidence suggests that stimulation of brain noradrenergic neurons plays an inhibitory role in rat mouse-killing (muricidal) aggression. Anxiolytic benzodiazepines inhibit locus coeruleus activity and previous data showed that chlordiazepoxide was capable of antagonizing the locus coeruleus-mediated suppression of muricidal aggression. The present experiments showed that this effect is common to new anxiolytic triazolobenzodiazepines and to other non-benzodiazepine derivatives with anxiolytic activity. In this framework, 10 mg/kg of buspirone, of 1-pyrimidine-piperazine and of MJ-13805 proved to be as active as 2.5 mg/kg of alprazolam and as 5 mg/kg of chlordiazepoxide in inhibiting the locus coeruleus-mediated suppression of muricidal aggression.
有证据表明，刺激脑去甲肾上腺素能神经元对大鼠杀鼠（嗜杀同类）攻击行为起抑制作用。抗焦虑苯二氮䓬类药物会抑制蓝斑核活动，先前的数据表明，氯氮䓬能够拮抗蓝斑核介导的对杀鼠攻击行为的抑制作用。目前的实验表明，这种效应在新型抗焦虑三唑苯二氮䓬类药物以及其他具有抗焦虑活性的非苯二氮䓬衍生物中都很常见。在此背景下，10毫克/千克的丁螺环酮、1-嘧啶-哌嗪和MJ-13805在抑制蓝斑核介导的对杀鼠攻击行为的抑制作用方面，被证明与2.5毫克/千克的阿普唑仑以及5毫克/千克的氯氮䓬活性相当。
