Mos J, Olivier B
CNS Pharmacology, Department of Pharmacology, Duphar B.V., Weesp, The Netherlands.
Psychopharmacology (Berl). 1989;97(2):152-3. doi: 10.1007/BF00442238.
The pro-aggressive effects of low doses of benzodiazepines on maternal aggression in rats were studied. Chlordiazepoxide, diazepam, oxazepam and alprazolam produced bell-shaped dose-response curves, with increased aggression at low doses. Only alprazolam significantly reduced aggression at higher doses. A comparison of the drug effects on different aggressive elements revealed that chlordiazepoxide and oxazepam increased the frequency of more elements of the aggressive repertoire than diazepam or alprazolam. Thus, although all benzodiazepine receptor agonists increased aggression, there were significant quantitative differences in their effects.
研究了低剂量苯二氮䓬类药物对大鼠母性行为攻击的促进作用。氯氮卓、地西泮、奥沙西泮和阿普唑仑产生钟形剂量反应曲线，低剂量时攻击行为增加。只有阿普唑仑在高剂量时显著降低攻击行为。对不同攻击元素的药物作用进行比较发现，氯氮卓和奥沙西泮比地西泮或阿普唑仑增加了更多攻击行为元素的发生频率。因此，尽管所有苯二氮䓬受体激动剂都增加了攻击行为，但它们的作用存在显著的定量差异。
