Horstmann M
J Pharm Pharmacol. 1984 Nov;36(11):770-1. doi: 10.1111/j.2042-7158.1984.tb04871.x.
Nicotine hypothermia is known as a central effect of nicotine waning after repeated administration due to the development of tolerance. In the present experiments using female rats, this tolerance was attenuated by the concomitant administration of mecamylamine. Atropine was without effect. It is concluded that tolerance to this effect of nicotine implies its contact with specific sites within the cns.
尼古丁体温过低被认为是反复给药后由于耐受性发展导致尼古丁作用减弱的一种中枢效应。在本实验中，使用雌性大鼠，同时给予美加明可减弱这种耐受性。阿托品则无此作用。由此得出结论，对尼古丁这种效应的耐受性意味着其与中枢神经系统内的特定部位发生了接触。
