Modak A T, Alderete B E
Pharmacology. 1986;32(1):46-51. doi: 10.1159/000138151.
An anesthetic dose of 50 mg/kg (i.p.) sodium pentobarbital caused a 61% increase in blood glucose levels in mice. Nicotine (2.5 mg/kg) given intraperitoneally 15 min prior to the sodium pentobarbital treatment further increased hyperglycemia by 29% over pentobarbital alone and 90% higher than the control. Mecamylamine (0.5 mg/kg) given intraperitoneally 15 min prior to nicotine resulted in blood glucose concentrations near the control value. Atropine (2 mg/kg) administered intraperitoneally did not prevent the hyperglycemia induced by nicotine and pentobarbital. No significant correlation was observed between the sleep time and the blood glucose of the unconscious or awake mice. However, a significant correlation was observed between the blood glucose concentration of the sleeping and awake mice. Blood glucose levels were always higher when the neuronal activity was depressed and were lower when the neuronal activity was increased.
腹腔注射50毫克/千克的戊巴比妥钠麻醉剂量可使小鼠血糖水平升高61%。在戊巴比妥钠治疗前15分钟腹腔注射尼古丁（2.5毫克/千克），与单独使用戊巴比妥钠相比，可使高血糖症进一步增加29%，比对照组高90%。在尼古丁注射前15分钟腹腔注射美加明（0.5毫克/千克），可使血糖浓度接近对照值。腹腔注射阿托品（2毫克/千克）不能预防尼古丁和戊巴比妥钠诱导的高血糖症。在无意识或清醒小鼠的睡眠时间和血糖之间未观察到显著相关性。然而，在睡眠和清醒小鼠的血糖浓度之间观察到显著相关性。当神经元活动受抑制时，血糖水平总是较高，而当神经元活动增加时，血糖水平较低。
