Paired helical filaments in spinal ganglion neurons of elderly rats.
作者信息
van den Bosch de Aguilar P, Goemaere-Vanneste J
出版信息
Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;47(3):217-22. doi: 10.1007/BF02890205.
PMID:6151303
Abstract
Ultrastructural study of spinal ganglion neurons in elderly rats (aged from 24 to 32 months) allowed the observation of spontaneously occurring paired helical filaments (PHFs). On the basis of this finding the rat may provide an animal model for the study of the morphogenesis and nature of the PHFs which are characteristic of human senile dementia of the Alzheimer type.
摘要
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