[Effect of obzidan, tropaphen, adrenaline and euphylline on histamine bronchospasm in guinea pigs].

It has been demonstrated in experiments on guinea-pigs that the beta-adrenoblocker propranolol (1-2 mg/kg) substantially raises bronchial sensitivity to histamine (10 mg/kg). The alpha-adrenoblocker tropaphen (2 mg/kg) potentiates the protective action of adrenaline (5 micrograms/kg) and euphylline (8 mg/kg) in bronchospasm induced by histamine (10 micrograms/kg).