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[吗啡和纳洛酮对组胺及5-羟色胺所致支气管痉挛的作用]

[The effect of morphine and naloxone on histamine- and serotonin-induced bronchospasms].

作者信息

Karpov O I

出版信息

Farmakol Toksikol. 1990 Jan-Feb;53(1):36-8.

PMID:2158463
Abstract

The effects of morphine and naloxone on bronchospasm induced by histamine and serotonin were studied on conscious rats. Morphine was found to increase histamine-induced bronchospasm and to prevent serotonin-induced bronchoconstriction. Naloxone prevented histamine-induced bronchospasm and exerted no effect on serotonin-induced bronchospasm.

摘要

在清醒大鼠身上研究了吗啡和纳洛酮对组胺和5-羟色胺诱导的支气管痉挛的影响。发现吗啡会加剧组胺诱导的支气管痉挛，并预防5-羟色胺诱导的支气管收缩。纳洛酮可预防组胺诱导的支气管痉挛，对5-羟色胺诱导的支气管痉挛则无作用。

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