甲状腺素对豚鼠实验性支气管痉挛的影响。
Effect of thyroxine on experimental bronchospasm in guinea pigs.
作者信息
Das D N, Bagchi D, Mandal S, De K, Chaudhuri S B, Dutta S, Roy K, Roy G, Saha S
机构信息
Department of Pharmacology, Burdwan Medical College.
出版信息
Indian J Physiol Pharmacol. 1995 Jul;39(3):290-2.
PMID:8550129
Abstract
Effect of Thyroxine was studied in histamine induced bronchospasm in guinea pigs. Chronic treatment with the drug significantly protected against experimental bronchospasm. Thyroxine also potentiated salbutamol evoked bronchodilation in this experimental model. Up-regulation of beta-2 adrenoceptors in bronchial smooth muscle may be the probable mechanism of action of thyroxine.
摘要
研究了甲状腺素对组胺诱导的豚鼠支气管痉挛的作用。长期使用该药物可显著预防实验性支气管痉挛。在该实验模型中，甲状腺素还增强了沙丁胺醇引起的支气管扩张作用。支气管平滑肌中β-2肾上腺素能受体的上调可能是甲状腺素的可能作用机制。
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