Pendergrass P B, Scott J N, Ream L J, Agna M A
Gynecol Obstet Invest. 1984;18(5):238-43. doi: 10.1159/000299088.
50 subjects participated in a 4-month study of the effects of an antihistamine on total menstrual loss. During the first 2 periods, no drugs were given; during the last 2 periods, an antihistamine or a placebo was administered according to a double-blind format. The menstrual weights of the first 2 months were averaged and compared with averages from the last 2 months combined. The treated group showed an average decrease in menstrual loss of 11.30 g compared to a decrease of 0.98 g in the placebo group. While the difference in means was not statistically significant, the variance between the 2 groups was significant (p = 0.0002), indicating that the antihistamine, chlorpheniramine maleate, was effective in reducing menstrual loss in certain individuals, but that the effect was neither uniform nor universal.
50名受试者参与了一项为期4个月的关于抗组胺药对月经失血总量影响的研究。在前两个月经周期，未给予任何药物；在最后两个月经周期，按照双盲模式给予抗组胺药或安慰剂。计算前两个月月经出血量的平均值，并与后两个月合并后的平均值进行比较。治疗组月经失血量平均减少了11.30克，而安慰剂组减少了0.98克。虽然两组均值差异无统计学意义，但两组之间的方差具有显著性（p = 0.0002），表明抗组胺药马来酸氯苯那敏对某些个体减少月经失血有效，但效果既不统一也不普遍。
