β-肾上腺素能受体阻断对绵羊前列环素介导的肾素释放的影响。
Effects of beta-adrenoceptor blockade on prostacyclin mediated renin release in sheep.
作者信息
Mason R T, Coghlan J P, Denton D A, Fei D W, Whitworth J A, Scoggins B A
出版信息
Clin Exp Pharmacol Physiol. 1984 Nov-Dec;11(6):571-7. doi: 10.1111/j.1440-1681.1984.tb00869.x.
Abstract
The effect of prostacyclin (PGI2) infusion on plasma renin concentration (PRC) was examined before and after propranolol treatment in sheep. Increasing doses of prostacyclin (0.05, 0.1 or 0.3 micrograms/kg per min) produced dose dependent increases in PRC. There was a significantly lower PRC response after propranolol at 0.3 micrograms/kg per min only.
摘要
在绵羊中，研究了前列环素（PGI2）输注对血浆肾素浓度（PRC）的影响，该研究在普萘洛尔治疗前后进行。递增剂量的前列环素（0.05、0.1或0.3微克/千克每分钟）使PRC呈剂量依赖性增加。仅在0.3微克/千克每分钟的普萘洛尔治疗后，PRC反应显著降低。
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