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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Mason R T, Allen K J, Coghlan J P, Denton D A, Fei D T, Graham W F, Scoggins B A, Stewart K W

Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):469-72. doi: 10.1111/j.1440-1681.1980.tb00093.x.

The haemodynamic effects of short-term prostacyclin infusions (0.05-0.50 microgram/kg per min) were investigated in conscious adult sheep. 2. Haemodynamic dose-response curves to prostacyclin were performed before, during and after production of ACTH-induced hypertension. 3. Prior to ACTH administration prostacyclin produced dose-dependent reductions in mean arterial pressure, total peripheral resistance and stroke volume and these were accompanied by increased in heart rate and cardiac output. 4. After 5 days of ACTH-induced hypertension prostacyclin produced similar effects on mean arterial pressure to those seen prior to ACTH but the effects on heart rate, cardiac output, stroke volume and total peripheral resistance were markedly increased. 5. These studies demonstrate that the responsiveness of the circulation to prostacyclin is altered in ACTH-induced hypertension.

在清醒的成年绵羊中研究了短期输注前列环素（0.05 - 0.50微克/千克每分钟）的血流动力学效应。2. 在促肾上腺皮质激素（ACTH）诱导的高血压产生之前、期间和之后，进行了对前列环素的血流动力学剂量反应曲线实验。3. 在给予ACTH之前，前列环素使平均动脉压、总外周阻力和每搏量呈剂量依赖性降低，同时伴有心率和心输出量增加。4. 在ACTH诱导高血压5天后，前列环素对平均动脉压产生的影响与给予ACTH之前相似，但对心率、心输出量、每搏量和总外周阻力的影响明显增强。5. 这些研究表明，在ACTH诱导的高血压中，循环系统对前列环素的反应性发生了改变。

Mason R T, Allen K J, Coghlan J P, Denton D A, Fei D T, Graham W F, Scoggins B A, Stewart K W

Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):469-72. doi: 10.1111/j.1440-1681.1980.tb00093.x.

The haemodynamic effects of short-term prostacyclin infusions (0.05-0.50 microgram/kg per min) were investigated in conscious adult sheep. 2. Haemodynamic dose-response curves to prostacyclin were performed before, during and after production of ACTH-induced hypertension. 3. Prior to ACTH administration prostacyclin produced dose-dependent reductions in mean arterial pressure, total peripheral resistance and stroke volume and these were accompanied by increased in heart rate and cardiac output. 4. After 5 days of ACTH-induced hypertension prostacyclin produced similar effects on mean arterial pressure to those seen prior to ACTH but the effects on heart rate, cardiac output, stroke volume and total peripheral resistance were markedly increased. 5. These studies demonstrate that the responsiveness of the circulation to prostacyclin is altered in ACTH-induced hypertension.

在清醒的成年绵羊中研究了短期输注前列环素（0.05 - 0.50微克/千克每分钟）的血流动力学效应。2. 在促肾上腺皮质激素（ACTH）诱导的高血压产生之前、期间和之后，进行了对前列环素的血流动力学剂量反应曲线实验。3. 在给予ACTH之前，前列环素使平均动脉压、总外周阻力和每搏量呈剂量依赖性降低，同时伴有心率和心输出量增加。4. 在ACTH诱导高血压5天后，前列环素对平均动脉压产生的影响与给予ACTH之前相似，但对心率、心输出量、每搏量和总外周阻力的影响明显增强。5. 这些研究表明，在ACTH诱导的高血压中，循环系统对前列环素的反应性发生了改变。