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放射性磷对乳腺癌和前列腺癌转移性骨病变姑息治疗的评估。

Evaluation of radioactive phosphorus in the palliation of metastatic bone lesions from carcinoma of the breast and prostate.

作者信息

Cheung A, Driedger A A

出版信息

Radiology. 1980 Jan;134(1):209-12. doi: 10.1148/radiology.134.1.6153129.

DOI:10.1148/radiology.134.1.6153129
PMID:6153129
Abstract

Radioactive phosphorus effected substantial palliation of intractable bone pain in 17 of 33 (51.5%) women with metastatic carcinoma of the breast and in 14 of 15 (93.3%) men with metastatic carcinoma of the prostate. No significant difference in the overall response rate was found between androgen and parathormone priming prior to radiophosphorus therapy. The degree of response was not dependent on total dose of 32P within the range of 9--18 mCi (333--666 MBq). Myelosuppression was a transient complication in 9 of 33 patients with metastatic breast carcinoma and in 7 of 15 patients with metastatic prostate carcinoma. Symptomatic hypercalcemia was an infrequent complication of radiophosphorus therapy irrespective of the priming regimen.

摘要

放射性磷使33例(51.5%)转移性乳腺癌女性患者中的17例以及15例(93.3%)转移性前列腺癌男性患者中的14例顽固性骨痛得到显著缓解。在放射性磷治疗前,雄激素和甲状旁腺素预处理之间的总体缓解率未发现显著差异。在9 - 18 mCi(333 - 666 MBq)范围内,缓解程度不依赖于32P的总剂量。骨髓抑制是33例转移性乳腺癌患者中的9例以及15例转移性前列腺癌患者中的7例的短暂并发症。无论预处理方案如何,症状性高钙血症都是放射性磷治疗的罕见并发症。

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Evaluation of radioactive phosphorus in the palliation of metastatic bone lesions from carcinoma of the breast and prostate.放射性磷对乳腺癌和前列腺癌转移性骨病变姑息治疗的评估。
Radiology. 1980 Jan;134(1):209-12. doi: 10.1148/radiology.134.1.6153129.
2
Radiophosphorous (P32) treatment in carcinoma of the breast and prostate: report of 39 cases.放射性磷(P32)治疗乳腺癌和前列腺癌:39例报告。
J Am Osteopath Assoc. 1974 Nov;74(3):217-22.
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Phosphorus-32 for intractable pain in carcinoma of prostate. Analysis of androgen priming, parathormone rebound, and combination therapy.磷-32治疗前列腺癌顽固性疼痛。雄激素启动、甲状旁腺素反弹及联合治疗分析。
Urology. 1977 Feb;9(2):137-9. doi: 10.1016/0090-4295(77)90182-0.
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Treatment of metastatic carcinoma of the prostate to bone with parathormone and radioactive phosphorous.用甲状旁腺素和放射性磷治疗前列腺癌骨转移
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Urology. 1973 Mar;1(3):201-4. doi: 10.1016/0090-4295(73)90735-8.
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[Radioactive substances (32P and 89Sr) in the treatment of pain in bone metastases].[放射性物质(32P和89Sr)治疗骨转移疼痛]
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Editorial: Treatment of bone metastases from carcinoma of prostate with parathyroid hormone and radioactive phosphorus.社论:用甲状旁腺激素和放射性磷治疗前列腺癌骨转移
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