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玻璃体内注射皮质类固醇抑制眼内增殖。

Inhibition of intraocular proliferations with intravitreal corticosteroids.

作者信息

Tano Y, Sugita G, Abrams G, Machemer R

出版信息

Am J Ophthalmol. 1980 Jan;89(1):131-6. doi: 10.1016/0002-9394(80)90239-1.

DOI:10.1016/0002-9394(80)90239-1
PMID:6153251
Abstract

Autotransplantation of one fourth million tissue cultured fibroblasts from rabbit rump skin into the vitreous cavity resulted in intravitreal strand formation and traction retinal detachment (27 of 47 eyes, 57%). A single intravitreal injection of 1 mg of dexamethasone alcohol inhibited fibroblast growth as judged by the significantly reduced number of retinal detachments (11 of 46 eyes, 24%). Retinal neovascularization that was observed when fibrous strands came into contact with vascularized retina (nine of 47 eyes, 19%) was also inhibited after corticosteroid application (two of 46 eyes, 4%).

摘要

将40万个来自兔臀部皮肤的组织培养成纤维细胞自体移植到玻璃体腔中,导致玻璃体条索形成和牵拉性视网膜脱离(47只眼中有27只,占57%)。通过视网膜脱离数量显著减少判断,单次玻璃体内注射1毫克地塞米松醇可抑制成纤维细胞生长(46只眼中有11只,占24%)。当纤维条索与血管化视网膜接触时观察到的视网膜新生血管(47只眼中有9只,占19%)在应用皮质类固醇后也受到抑制(46只眼中有2只,占4%)。

相似文献

1
Inhibition of intraocular proliferations with intravitreal corticosteroids.玻璃体内注射皮质类固醇抑制眼内增殖。
Am J Ophthalmol. 1980 Jan;89(1):131-6. doi: 10.1016/0002-9394(80)90239-1.
2
Treatment of intraocular proliferations with intravitreal steroids.
Trans Am Ophthalmol Soc. 1979;77:171-80.
3
Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide.玻璃体内注射曲安奈德治疗眼内增殖。
Am J Ophthalmol. 1980 Dec;90(6):810-6. doi: 10.1016/s0002-9394(14)75196-7.
4
Retinal neovascularization after intravitreal fibroblast injection.玻璃体内注射成纤维细胞后的视网膜新生血管形成。
Am J Ophthalmol. 1981 Jul;92(1):103-9. doi: 10.1016/s0002-9394(14)75913-6.
5
Intravitreal autotransplantation of fibroblasts.玻璃体内成纤维细胞自体移植
Am J Ophthalmol. 1980 Jan;89(1):121-30. doi: 10.1016/0002-9394(80)90238-x.
6
Experimental Fibroplasia in the rabbit vitreous. Retinal detachment induced by autologous fibroblasts.兔玻璃体中的实验性纤维组织形成。自体成纤维细胞诱导的视网膜脱离。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 May 26;199(3):215-22. doi: 10.1007/BF00417290.
7
[Clinical and experimental results in the treatment of massive periretinal proliferation (MPP), a retinal detachment with a most unfavorable prognosis].
Wien Klin Wochenschr Suppl. 1982;139:1-32.
8
The role of cellular proliferation in an experimental model of massive periretinal proliferation.细胞增殖在大规模视网膜周边增殖实验模型中的作用。
Am J Ophthalmol. 1982 May;93(5):565-72. doi: 10.1016/s0002-9394(14)77370-2.
9
Prevention of experimental massive peri-retinal proliferation by 5-fluoro-uracil.
Metab Pediatr Syst Ophthalmol. 1983;7(2):109-13.
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Vascular casts of experimental retinal neovascularization.实验性视网膜新生血管的血管铸型
Am J Ophthalmol. 1981 Jul;92(1):110-20. doi: 10.1016/s0002-9394(14)75914-8.

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