Mattern C F, Keister D B, Natovitz P C
Am J Trop Med Hyg. 1980 Jan;29(1):26-30. doi: 10.4269/ajtmh.1980.29.26.
Extracts of Entamoeba histolytica produce rounding and agglutination of mammalian cells in tissue culture. This effect is inhibited or reversed by serum, by the serum glycoprotein, fetuin, or by N-acetyl-D-galactosamine. Concanavalin A produces a similar cytotoxic effect that is blocked or reversed by alpha-methyl mannoside. These properties suggest that the amebal "toxin" has a lectin-like activity.
溶组织内阿米巴提取物在组织培养中可使哺乳动物细胞变圆并发生凝集。血清、血清糖蛋白胎球蛋白或N-乙酰-D-半乳糖胺可抑制或逆转这种效应。伴刀豆球蛋白A可产生类似的细胞毒性效应，α-甲基甘露糖苷可阻断或逆转这种效应。这些特性表明，阿米巴“毒素”具有类凝集素活性。
