急性白血病中的吞噬作用。

Phagocytosis in acute leukemia.

作者信息

Glasser L

出版信息

Cancer. 1980 Mar 15;45(6):1365-9. doi: 10.1002/1097-0142(19800315)45:6<1365::aid-cncr2820450615>3.0.co;2-i.

DOI:10.1002/1097-0142(19800315)45:6<1365::aid-cncr2820450615>3.0.co;2-i

Abstract

The phagocytic potential of leukemic cells in various types of acute leukemia was studied. Cases included lymphoblastic leukemia, myeloblastic leukemia, myelomonocytic leukemia, monocytic leukemia, progranulocytic leukemia, blast transformation of chronic myelocytic leukemia, and unclassified leukemias. Cytochemical stains were used as an aid in classification. These included Sudan black B, naphthol AS-D chloroacetate esterase, alpha-naphthyl butyrate esterase, acid phosphatase, and periodic acid-Schiff. Phagocytosis was evaluated after incubation of leukemic cells with Candida albicans. Rare phogocytic activity was seen in lymphoblastic leukemia, unclassified leukemias, blast crises in chronic myelocytic leukemia, and progranulocytic leukemia. Myeloblastic leukemias were feebly phagocytic. Myelomonocytic leukemia and monocytic leukemia both exhibited marked phagocytosis which distinguished them from the other acute leukemias. Myelomonocytic leukemia could be differentiated from acute monocytic leukemia by its greater phagocytic capacity.

摘要

对各类急性白血病中白血病细胞的吞噬潜力进行了研究。病例包括淋巴细胞白血病、粒细胞白血病、粒单核细胞白血病、单核细胞白血病、早幼粒细胞白血病、慢性粒细胞白血病急变以及未分类白血病。细胞化学染色辅助进行分类。这些染色包括苏丹黑B、萘酚AS-D氯乙酸酯酶、α-萘丁酸酯酶、酸性磷酸酶和过碘酸-希夫反应。白血病细胞与白色念珠菌孵育后评估吞噬作用。在淋巴细胞白血病、未分类白血病、慢性粒细胞白血病急变和早幼粒细胞白血病中可见罕见的吞噬活性。粒细胞白血病的吞噬作用较弱。粒单核细胞白血病和单核细胞白血病均表现出明显的吞噬作用，这使其与其他急性白血病相区别。粒单核细胞白血病可因其更强的吞噬能力与急性单核细胞白血病相鉴别。