Li C Y, Phyliky R L, Yam L T
Mayo Clin Proc. 1986 Feb;61(2):104-9. doi: 10.1016/s0025-6196(12)65195-7.
By using the combination of alpha-naphthyl butyrate esterase and chloroacetate esterase for cytochemical detection of monocytes and granulocytes, respectively, we examined and identified five adult patients with acute myeloid leukemia whose leukemic cells often (20 to 30%) had the characteristics of both monocytes and granulocytes. All five patients were men, 23 to 82 years of age. Two patients had manifestations of preleukemia. One of these two patients had received treatment for lymphoma for 12 months before acute myelomonocytic leukemia was diagnosed. One patient had gum hypertrophy, and two had leukemia cutis. At the time of initial examination, four patients had blood leukocyte counts higher than 80,000/mm3 and one had leukopenia. Four patients received chemotherapy; three responded temporarily but died within 1 year after the myelomonocytic leukemia had been diagnosed. The patient with leukopenia has remained in complete remission for 2 years. With more frequent use of double esterase stains for classification of acute myeloid leukemias, this variant of acute myelomonocytic leukemia should be detected more often and its clinical behavior should be better understood.
通过分别使用α-萘丁酸酯酶和氯乙酸酯酶联合进行细胞化学检测单核细胞和粒细胞，我们检查并鉴定了5例成年急性髓系白血病患者，其白血病细胞常（20%至30%）具有单核细胞和粒细胞的特征。所有5例患者均为男性，年龄在23至82岁之间。2例患者有白血病前期表现。这2例患者中的1例在急性粒单核细胞白血病诊断前曾接受淋巴瘤治疗12个月。1例患者有牙龈增生，2例有白血病性皮肤浸润。初诊时，4例患者血白细胞计数高于80,000/mm³，1例有白细胞减少。4例患者接受了化疗；3例有暂时反应，但在粒单核细胞白血病诊断后1年内死亡。白细胞减少的患者已完全缓解2年。随着双酯酶染色更频繁地用于急性髓系白血病的分类，这种急性粒单核细胞白血病的变异型应更常被检测到，其临床行为也应得到更好的了解。
