Saito I, Eguchi T, Nakamura R, Misumi J, Kondo K, Saruta T
Jpn Heart J. 1980 Jan;21(1):95-101. doi: 10.1536/ihj.21.95.
The effects of angiotensin converting enzyme inhibitor (CEI) upon blood pressure and plasma aldosterone (PA) were studied in rabbits with a simultaneous infusion of angiotensin I (ANG I) or with hemorrhagic hypotension. Pretreatment with CEI (SQ 20881), 1.0 mg/Kg, inhibited the effects of infused ANG I, 30 ng/Kg/min, upon PA and blood pressure at 30 min of the infusion, but the inhibition on PA was not significant at 60 min of the infusion. The same dose of CEI was ineffective in blocking the effect of 100 ng/Kg/min of ANG I on PA and blood pressure even at 30 min of the infusion. In rabbits with hemorrhagic hypotension, injection of CEI resulted in the decrement in blood pressure, whereas no decrement in blood pressure was observed in normal control rabbits. This study suggests that CEI exerts it's effect in part by inhibiting conversion of ANG I to angiotensin II (ANG II), but this can't exclude other mechanisms.
在同时输注血管紧张素I（ANG I）或出血性低血压的家兔中，研究了血管紧张素转换酶抑制剂（CEI）对血压和血浆醛固酮（PA）的影响。用1.0mg/Kg的CEI（SQ 20881）预处理，在输注30分钟时抑制了30ng/Kg/min输注的ANG I对PA和血压的影响，但在输注60分钟时对PA的抑制作用不显著。即使在输注30分钟时，相同剂量的CEI也无法阻断100ng/Kg/min的ANG I对PA和血压的影响。在出血性低血压的家兔中，注射CEI导致血压下降，而正常对照家兔未观察到血压下降。本研究表明，CEI部分通过抑制ANG I向血管紧张素II（ANG II）的转化发挥作用，但这不能排除其他机制。
