Tal C, Herberman R B, Gail M, Schutt A
J Natl Cancer Inst. 1980 May;64(5):1007-14.
We evaluated the ability of polyacrylamide gel electrophoresis (PAGE) to measure protein band No. 1 (PB1) in serum as a means of discriminating between the sera of cancer patients and controls. Serum samples from 123 cancer patients, 155 subjects without clinically diagnosed cancer, and 6 members of families with a high incidence of cancer (total, 284) were obtained in Israel. An additional 214 serum samples from 80 cancer patients and 134 subjects without cancer were obtained from the Mayo Clinic-National Cancer Institute Serum Bank. Although a significantly higher proportion of serum specimens from cancer patients had positive results for PB1 by the PAGE method, the test at its current stage of development does not seem sufficiently discriminating for use in screening for cancer.
我们评估了聚丙烯酰胺凝胶电泳（PAGE）测量血清中蛋白带1（PB1）的能力，以此作为区分癌症患者和对照者血清的一种方法。在以色列采集了123名癌症患者、155名未被临床诊断为癌症的受试者以及6名癌症高发家族成员（共284人）的血清样本。另外还从梅奥诊所 - 美国国立癌症研究所血清库获得了80名癌症患者和134名非癌症受试者的214份血清样本。尽管通过PAGE方法检测，癌症患者血清标本中PB1呈阳性的比例明显更高，但该检测方法在其目前的发展阶段似乎不足以用于癌症筛查。
