Laurová L, Jandová A, Pezlarová J, Skoda V
Acta Univ Carol Med Monogr. 1977(78 Pt 2):125-9.
We investigated the serum activity of the fifth fraction of L-lactate: NAD-oxidoreductase (E.C.1.1.1.27) and serum alkaline phosphatase activity prior to diagnostic curettage in patients with abnormal and atypical endomertial hyperplasia. We also determined them in 75 patients with carcinoma of the endometrium, 80 patients with glandular cystic endometrial hyperplasia and a "normal" control group of 70 patients. In the statistical evaluation we found a significantly high incidence of low AP activity and elevated LDH5 in the group of patients with glandular cystic endometrial hyperplasia, as well as in patients with precancerous lesions of the endometrium and carcinoma of the endometrium. The findings raise the question of whether these changes in the serum activity of the given enzymes are only a response to a given hormonal modulation.
我们研究了异常和非典型子宫内膜增生患者诊断性刮宫术前血清中L-乳酸：NAD氧化还原酶（E.C.1.1.1.27）第五组分的活性以及血清碱性磷酸酶活性。我们还测定了75例子宫内膜癌患者、80例腺囊性子宫内膜增生患者以及70例“正常”对照组患者的上述指标。在统计学评估中，我们发现腺囊性子宫内膜增生患者组以及子宫内膜癌前病变和子宫内膜癌患者中，碱性磷酸酶活性低和乳酸脱氢酶5升高的发生率显著较高。这些发现提出了一个问题，即给定酶的血清活性变化是否仅仅是对特定激素调节的一种反应。
