Egg D, Herold M, Rumpl E, Günther R
J Neurol. 1980;222(4):239-48. doi: 10.1007/BF00313153.
Prostaglandin F2 alpha concentrations in cerebrospinal fluid (CSF) from normal human subjects and patients with various pathological disorders of the central nervous system (CNS) were measured by radioimmunoassay. The mean PGF2 alpha level in 54 controls with no evidence of organic CNS disease was 67 pg/ml (range: 25-150 pg/ml). A significant increase of PGF2 alpha levels was demonstrated in most samples from patients with CNS diseases. Extremely high values were found in patients with stroke and subarachnoid hemorrhage when samples were collected shortly after the cerebral attack. With the regression of clinical symptoms and radiological findings a decrease of PGF2 alpha levels was demonstrated in this group of patients. In 32 patients with cerebral transient ischemic attacks a mean PGF2 alpha concentration of 170 pg/ml (range: 35-355 pg/ml) was found. Increased PGF2 alpha levels were found in patients with epilepsy when samples were collected within a few days after a convulsion. PGF2 alpha levels of four patients with slow progredient forms of multiple sclerosis without clinical symptoms at the time of sample collection were not different from normal controls while the mean PGF2 alpha level of all other patients with multiple sclerosis was 152 pg/ml (range: 55-325 pg/ml). Moreover, increased values could be demonstrated in patients with cerebral tumors and inflammatory processes.
采用放射免疫分析法测定了正常人和患有各种中枢神经系统（CNS）病理疾病患者脑脊液（CSF）中的前列腺素F2α浓度。54名无中枢神经系统器质性疾病证据的对照者的前列腺素F2α平均水平为67 pg/ml（范围：25 - 150 pg/ml）。在大多数中枢神经系统疾病患者的样本中，前列腺素F2α水平显著升高。在脑卒中及蛛网膜下腔出血患者脑部发作后不久采集样本时，发现其值极高。随着临床症状和影像学表现的消退，该组患者的前列腺素F2α水平降低。在32例脑短暂性缺血发作患者中，发现前列腺素F2α平均浓度为170 pg/ml（范围：35 - 355 pg/ml）。在癫痫患者抽搐后数天内采集样本时，发现前列腺素F2α水平升高。4例样本采集时无临床症状的缓慢进展型多发性硬化患者的前列腺素F2α水平与正常对照无差异，而所有其他多发性硬化患者的前列腺素F2α平均水平为152 pg/ml（范围：55 - 325 pg/ml）。此外，在脑肿瘤和炎症性疾病患者中也发现了升高的值。
