Tamai I, Takei T, Maekawa K, Ohta H
Brain Dev. 1983;5(4):357-62. doi: 10.1016/s0387-7604(83)80039-4.
Cerebrospinal fluid prostaglandin F2 alpha (CSF PGF2 alpha) levels were measured by radioimmunoassay in children as follows: Febrile convulsions (31 cases), epilepsies (32 cases), meningitides (31 cases) and non-neurological diseases (20 cases), totaling 114 cases. A 4.5-fold increase in CSF PGF2 alpha levels was seen in simple febrile convulsion, and a 2.5-fold increase in those with complex febrile convulsion as compared to those with non-neurological diseases. On the other hand, no increase in CSF PGF2 alpha levels was seen in children with epilepsy. When the body temperature was normal, the mean CSF PGF2 alpha levels showed no relation with age. When the body temperature was between 37.5 degrees C and 40 degrees C, the CSF PGF2 alpha levels in infants were higher than those in older children. The CSF PGF2 alpha levels in children with meningitis were high. The mean CSF PGF2 alpha levels in bacterial meningitis were not statistically (p greater than 0.05) different from those in viral meningitis. The CSF PGF2 alpha levels in meningitis were high on admission and gradually decreased with therapy. The results of our studies indicate that PGF2 alpha of the central nervous system markedly increased in infants and children with febrile convulsions or meningitis but not in those with epilepsy.
采用放射免疫分析法测定了如下儿童脑脊液中前列腺素F2α（CSF PGF2α）水平：热性惊厥（31例）、癫痫（32例）、脑膜炎（31例）和非神经系统疾病（20例），共114例。与非神经系统疾病患儿相比，单纯热性惊厥患儿CSF PGF2α水平升高4.5倍，复杂性热性惊厥患儿升高2.5倍。另一方面，癫痫患儿CSF PGF2α水平未见升高。体温正常时，CSF PGF2α平均水平与年龄无关。体温在37.5℃至40℃之间时，婴儿CSF PGF2α水平高于大龄儿童。脑膜炎患儿CSF PGF2α水平较高。细菌性脑膜炎患儿CSF PGF2α平均水平与病毒性脑膜炎患儿相比，差异无统计学意义（p＞0.05）。脑膜炎患儿入院时CSF PGF2α水平较高，治疗后逐渐下降。我们的研究结果表明，中枢神经系统的PGF2α在热性惊厥或脑膜炎婴幼儿中显著升高，但在癫痫患儿中未升高。
