Iagubov A S, Kats L A
Arkh Patol. 1980;42(1):50-6.
Twenty-three cases of squamous cell carcinoma of the lungs of various degrees of cataplasia were examined electron microscopically and in 12 cases of these a morphometric analysis of the tumour cell ultrastructure was done. The results showed keratohyalin to be present in squamous carcinoma cells both with and without keratinization; however, its content decreased with the increase of the tumor cataplasia. Thus the degree of development of keratohyalin may be the main objective criterion of the cataplasia degree of squamous cell carcinoma of the lungs. The increased activity of free polyribosomal apparatus with increasing cataplasia of the tumour, increased general synthetic activity of tumour cells as well as the strong correlation of these parameters with the volume fraction of keratohyalin are additional criteria of the degree of cataplasia of squamous cell carcinoma of the lung.
对23例不同程度化生的肺鳞状细胞癌进行了电子显微镜检查，并对其中12例肿瘤细胞超微结构进行了形态计量分析。结果显示，角化型和非角化型肺鳞状癌细胞中均存在透明角质颗粒；然而，其含量随肿瘤化生程度的增加而减少。因此，透明角质颗粒的发育程度可能是肺鳞状细胞癌化生程度的主要客观标准。随着肿瘤化生程度的增加，游离多核糖体活性增强，肿瘤细胞的总体合成活性增加，以及这些参数与透明角质颗粒体积分数的强相关性，是肺鳞状细胞癌化生程度的额外标准。
