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原发性高血压患者尿β-血小板球蛋白

Urinary beta-thromboglobulin in essential hypertension.

作者信息

Anderton J L, Fananapazir L, Dawes J

出版信息

Br J Haematol. 1980 Feb;44(2):307-11. doi: 10.1111/j.1365-2141.1980.tb01213.x.

DOI:10.1111/j.1365-2141.1980.tb01213.x
PMID:6155134
Abstract

Urinary concentrations of the platelet-specific protein beta-thromboglobulin (beta-TG) were measured in patients with essential hypertension. Values obtained for patients with normal renal function fell within the same population as those for a control group of normal individuals, but nevertheless 21% of these patients had urinary beta-TG values above the upper limit of the normal range. Values for patients with renal insufficiency were significantly different from the other groups, and 44% of these individuals had abnormally elevated urinary beta-TG concentrations. These elevated values may reflect an increased plasma concentration of beta-TG in patients with renal impairment or they could be an indicator of renal damage.

摘要

对原发性高血压患者的尿液中血小板特异性蛋白β-血小板球蛋白(β-TG)浓度进行了测量。肾功能正常的患者所测得的值与正常个体对照组的值处于同一范围内,但仍有21%的此类患者尿液β-TG值高于正常范围上限。肾功能不全患者的值与其他组有显著差异,且这些个体中有44%的人尿液β-TG浓度异常升高。这些升高的值可能反映了肾功能损害患者血浆中β-TG浓度的增加,或者它们可能是肾损伤的一个指标。

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