Devor M, Claman D
Brain Res. 1980 May 19;190(1):17-28. doi: 10.1016/0006-8993(80)91156-7.
After peripheral nerve injury in rats, naturally occurring fluoride resistant acid phosphatase (FRAP) disappears from the substantia gelatinosa in that part of the dorsal horn in which the injured nerve afferents terminate. We have taken advantage of this fact to establish the spinal distribution of nerves innervating the skin of the hindlimb. The spinal map of the foot, the distal part of the lower lumbar dermatomes, is in the medial part of the substantia gelatinosa. More proximal skin of the thigh and lower back maps laterally. The zone of disappearance of FRAP after sciatic nerve section did not shrink detectably within the first few months after injury, provided that regeneration of the nerve was prevented. After one year, however, central FRAP activity was at least partially restored. Secondary transection of the sciatic nerve eliminated the new enzyme and transection of neighboring nerves failed to do so. The restored FRAP activity therefore reflects renewed synthesis and transport of enzyme in still injured neurons, and not central sprouting of intact neighboring afferents.
大鼠外周神经损伤后，天然存在的耐氟酸性磷酸酶（FRAP）在背角中受伤神经传入纤维终止的那部分胶状质中消失。我们利用这一事实来确定支配后肢皮肤的神经在脊髓中的分布。足部的脊髓图谱，即下腰段皮节的远端部分，位于胶状质的内侧部分。大腿和下背部更近端的皮肤图谱位于外侧。坐骨神经切断后，FRAP消失的区域在损伤后的最初几个月内没有明显缩小，前提是神经再生被阻止。然而，一年后，中枢FRAP活性至少部分恢复。坐骨神经的二次横断消除了新的酶，而相邻神经的横断则没有。因此，恢复的FRAP活性反映了仍受损神经元中酶的重新合成和运输，而不是完整相邻传入纤维的中枢侧支发芽。
