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采用电化学检测法对尿液中5-羟基-3-吲哚乙酸进行液相色谱分析。

Liquid-chromatographic assay of urinary 5-hydroxy-3-indoleacetic acid, with electrochemical detection.

作者信息

Shihabi Z K, Scaro J

出版信息

Clin Chem. 1980 Jun;26(7):907-9.

PMID:6155229
Abstract

After extraction with two organic solvent mixtures, urinary 5-hydroxy-3-indoleacetic acid can be assayed by "high-performance" liquid chromatography on a reversed-phase column, with electrochemical detection. Compared to the nitrosonaphthol method (J. Biol. Chem. 216: 499, 1955), this method is more specific for detection of patients with carcinoid tumors.

摘要

用两种有机溶剂混合物萃取后，尿中5-羟基-3-吲哚乙酸可用反相柱高效液相色谱法并采用电化学检测进行测定。与亚硝基萘酚法（《生物化学杂志》216: 499, 1955）相比，该方法在检测类癌肿瘤患者时更具特异性。

相似文献

1
Liquid-chromatographic assay of urinary 5-hydroxy-3-indoleacetic acid, with electrochemical detection.采用电化学检测法对尿液中5-羟基-3-吲哚乙酸进行液相色谱分析。
Clin Chem. 1980 Jun;26(7):907-9.
2
Liquid-chromatographic determination of urinary 5-hydroxy-3-indoleacetic acid, with fluorescence detection.采用荧光检测的液相色谱法测定尿中5-羟基-3-吲哚乙酸。
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Colorimetric assay of urinary 5-hydroxy-3-indoleacetic acid.尿5-羟色胺酸的比色测定法。
Clin Biochem. 1982 Apr;15(2):106-8. doi: 10.1016/s0009-9120(82)96125-2.
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Urinary 4-hydroxy-3-methoxymandelic (vanillylmandelic) acid, 4-hydroxy-3-methoxyphenylacetic (homovanillic) acid, and 5-hydroxy-3-indoleacetic acid determined by liquid chromatography with electrochemical detection.
Clin Chem. 1983 May;29(5):876-8.
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Liquid-chromatographic separation of urinary 5-hydroxy-3-indoleacetic acid, with measurement at 254 nm.采用液相色谱法分离尿中5-羟色胺酸，并在254nm波长处进行测定。
Clin Chem. 1980 Jun;26(7):910-2.
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Simultaneous liquid chromatographic determination of vanillylmandelic acid, homovanillic acid, and 5-hydroxy-3-indoleacetic acid in urine, using isocratic elution and electrochemical detection.采用等度洗脱和电化学检测同时测定尿液中的香草扁桃酸、高香草酸和5-羟基-3-吲哚乙酸。
Biomed Chromatogr. 1987;2(3):115-9. doi: 10.1002/bmc.1130020307.
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Measurement of plasma 5-hydroxyindoleacetic acid in carcinoid disease: an alternative to 24-h urine collections?
Ann Clin Biochem. 2000 Sep;37 ( Pt 5):724-6. doi: 10.1258/0004563001899780.
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Determination of urinary 5-hydroxy-3-indoleacetic acid by an automated HPLC method.采用自动高效液相色谱法测定尿中5-羟基-3-吲哚乙酸。
Biomed Chromatogr. 1989 May;3(3):114-7. doi: 10.1002/bmc.1130030305.
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Fluorescence polarization immunoassay of urinary 5-hydroxy-3-indoleacetic acid.尿5-羟色胺的荧光偏振免疫测定法
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Simultaneous assay for urinary 4-hydroxy-3-methoxy-mandelic acid, 5-hydroxyindoleacetic acid and homovanillic acid by isocratic HPLC with electrochemical detection.
Ann Clin Biochem. 1989 Mar;26 ( Pt 2):137-43. doi: 10.1177/000456328902600208.

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