Retina contains guanine nucleotide sensitive and insensitive classes of dopamine receptors.
作者信息
Makman M H, Dvorkin B, Horowitz S G, Thal L J
出版信息
Eur J Pharmacol. 1980 May 2;63(2-3):217-22. doi: 10.1016/0014-2999(80)90450-1.
PMID:6155277
Abstract
Calf retina contains high affinity, stereospecific and saturable binding sites, characterized as dopaminergic, for 3H-spiropheridol (Bmax from Scatchard analysis = 38 +/- 4 fmoles/mg protein) and for 3H-ADTN (2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene). The 3H-ADTN sites include a discrete and saturable sub-set of sites sensitive to guanine nucleotide inhibition (Bmax = 50 +/- 6 fmoles/mg protein) and a separate saturable sub-set of sites insensitive to guanine nucleotides (Bmax = 63 +/- 7 fmoles/mg protein). The binding of agonists to 3H-spiroperidol sites is also inhibited by guanine nucleotides.
摘要
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