Holtz G, Baker E, Tsai C
Fertil Steril. 1980 Jun;33(6):660-2. doi: 10.1016/s0015-0282(16)44782-5.
Thirty-two per cent dextran 70 in dextrose (Hyskon) has been reported effective in limiting adhesion formation following a peritoneal injury when employed in doses larger than that known to be safe for intraperitoneal use in humans. The effectiveness of a lower dosage believed to be safe for human use was investigated. Female rabbits received a standardized injury to their uterine horns and proximal fallopian tubes. Following the injury, Hyskon (2.5 ml/kg of body weight) was dripped over the sites of injury in the treatment group. Animals were reoperated upon 2 weeks later, and adhesions were scored. Hyskon significantly reduced adhesion formation. In a second experiment the effect of Hyskon on adhesion re-formation was evaluated. Adhesions were induced in the same manner. Two weeks later, the animals were reoperated upon, and adhesions were scored and lysed. Hyskon was instilled in the treatment group as in the first experiment. No significant difference was noted between adhesion scores in control and treatment groups after adhesion induction or when re-evaluated 2 weeks after lysis.
据报道，当以高于已知对人体腹腔内使用安全剂量使用时，葡萄糖中32%的右旋糖酐70（海斯康）可有效限制腹膜损伤后粘连的形成。研究了一种据信对人体使用安全的较低剂量的有效性。雌性兔子的子宫角和近端输卵管受到标准化损伤。损伤后，治疗组在损伤部位滴注海斯康（2.5毫升/千克体重）。两周后对动物进行再次手术，并对粘连情况进行评分。海斯康显著减少了粘连的形成。在第二个实验中，评估了海斯康对粘连再形成的影响。以相同方式诱导粘连。两周后，对动物进行再次手术，并对粘连情况进行评分并松解。治疗组像在第一个实验中一样滴注海斯康。在诱导粘连后或在松解后两周重新评估时，对照组和治疗组的粘连评分没有显著差异。
