葡聚糖聚合物颗粒（葡聚糖凝胶G - 200）对体液免疫反应的影响。
Influence of dextran polymer particles (Sephadex G-200) on humoral immune responses.
作者信息
Ernst T M, Gillert K E, Müller S
出版信息
Int Arch Allergy Appl Immunol. 1980;62(4):463-6. doi: 10.1159/000232550.
Dextran polymer particles (Sephadex G-200) mixed with bovine serum albumin (BSA) or sheep red blood cells (SRBC) were injected intraperitoneally (i.p.) into mice and the number of antibody-forming cells in spleen and antibody titers in sera were determined. Antibody formation following the first and the booster immunization to BSA was enhanced to a similar degree by Sephadex G-200 and incomplete Freund's adjuvant. When SRBC were injected in a suboptimal dose of 5X10(6) cells, Sephadex G-200 enhanced the maximum of the primary immune response. In contrast, the polymer inhibited the primary and secondary immune response when 5X10(8) SRBC were given.
将与牛血清白蛋白（BSA）或绵羊红细胞（SRBC）混合的葡聚糖聚合物颗粒（葡聚糖G - 200）腹腔内（i.p.）注射到小鼠体内，然后测定脾脏中抗体形成细胞的数量和血清中的抗体滴度。葡聚糖G - 200和不完全弗氏佐剂对BSA初次免疫和加强免疫后的抗体形成增强程度相似。当以5×10⁶个细胞的次优剂量注射SRBC时，葡聚糖G - 200增强了初次免疫反应的最大值。相反，当给予5×10⁸个SRBC时，该聚合物抑制了初次和二次免疫反应。
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