Waxman A D, Richmond R, Juttner H, Siemsen J K, Heffelinger M J, Fink E
J Nucl Med. 1980 Apr;21(4):324-7.
Seventeen patients with histologically proven primary liver-cell carcinoma were evaluated by a technetium-99m sulfur colloid liver scan as well as with gallium-67 citrate. Twelve of the 17 patients (71%) showed gallium uptake in the tumor. Eleven of the 12 patients (92%) with a moderately or well-differentiated tumor showed increased gallium activity in the abnormality seen on the sulfur colloid scan. The exception in this group was a tumor with a large central area of necrosis. Four of five patients with a poorly differentiated or atypical carcinoma showed absence of gallium activity. Only six of 11 patients with a hypervascular tumor showed a marked increase in gallium uptake. Correlation of gallium with alpha-feto-protein, and with hepatitis antigen A, was poor. We conclude that gallium uptake in primary liver-cell carcinoma will be significant when the tumor shows a moderately to well-differentiated histologic pattern, unless significant necrosis is present. If the blood supply is markedly impaired, gallium uptake is reduced. However, a hypervascular blood supply does not necessarily ensure increased gallium avidity.
对17例经组织学证实的原发性肝细胞癌患者进行了99m锝硫胶体肝扫描和枸橼酸镓扫描评估。17例患者中有12例（71%）肿瘤部位有镓摄取。12例中度或高分化肿瘤患者中有11例（92%）在硫胶体扫描显示的异常部位镓活性增加。该组中的例外是一个有大片中央坏死区的肿瘤。5例低分化或非典型癌患者中有4例镓无活性。11例血管丰富的肿瘤患者中只有6例镓摄取显著增加。镓与甲胎蛋白以及甲型肝炎抗原的相关性较差。我们得出结论，原发性肝细胞癌中，除非存在明显坏死，否则当肿瘤呈中度至高分化组织学模式时，镓摄取将显著。如果血液供应明显受损，镓摄取会减少。然而，血管丰富的血液供应不一定能确保镓亲和力增加。
