Wood J H
Neurology. 1980 Jun;30(6):645-51. doi: 10.1212/wnl.30.6.645.
The use of cerebrospinal fluid (CSF) analysis for studying in vivo alterations in central neuronal activity requires a relatively sophisticated knowledge of CSF physiology and pathology. Ventriculospinal concentration gradients, circadian rhythms, physical activity, stress, medications, precursor intake, concomitant illness, obstructed CSF circulation, age, and sex alter the baseline neurochemical composition of CSF. Differential probenecid blockade of the egress of acidic monoamine metabolites and cyclic nucleotides from the CSF may complicate interpretations of their accumulations. Degradation of CSF constituents during collection, storage, and analysis may introduce errors in quantification. These sources of CSF variability can be minimized with proper methodolology.
使用脑脊液（CSF）分析来研究中枢神经元活动的体内变化，需要对CSF生理学和病理学有相对深入的了解。脑室脊髓浓度梯度、昼夜节律、身体活动、压力、药物、前体摄入、伴发疾病、CSF循环受阻、年龄和性别都会改变CSF的基线神经化学成分。丙磺舒对酸性单胺代谢产物和环核苷酸从CSF中流出的差异性阻断，可能会使对它们积累的解释变得复杂。在采集、储存和分析过程中CSF成分的降解可能会在定量方面引入误差。通过适当的方法可以将这些CSF变异性来源降至最低。
