神经系统疾病中的血浆和脑脊液γ-氨基丁酸
Plasma and cerebrospinal fluid gamma-aminobutyric acid in neurological disorders.
作者信息
Schmidt D, Löscher W
出版信息
J Neurol Neurosurg Psychiatry. 1982 Oct;45(10):931-5. doi: 10.1136/jnnp.45.10.931.
Abstract
In 49 patients with various neurological disorders plasma and CSF gamma-aminobutyric acid (GABA) concentrations were determined by radioreceptor assay. The CSF GABA concentration of 127 +/- 47 pmol/ml (range: 65-275; n = 52) was independent of the age, the sex and the intake of various drugs including benzodiazepines, baclofen and antidepressants. Patients with diverse neurological disorders such as multiple sclerosis, ischaemic strokes, intracranial tumour and polyneuropathies had similar CSF GABA levels. The mean plasma GABA concentration was 309 +/- 79 pmol/ml (range: 179-498; n = 44). The correlation between the GABA concentrations of CSF and plasma was very poor (r = 0.18; n = 44). Therefore plasma GABA is not a suitable indicator for CSF GABA.
摘要
采用放射受体分析法测定了49例患有各种神经系统疾病患者的血浆和脑脊液中γ-氨基丁酸（GABA）的浓度。脑脊液中GABA浓度为127±47 pmol/ml（范围：65 - 275；n = 52），与年龄、性别以及包括苯二氮䓬类、巴氯芬和抗抑郁药在内的各种药物的摄入无关。患有多种神经系统疾病（如多发性硬化症、缺血性中风、颅内肿瘤和多发性神经病）的患者脑脊液GABA水平相似。血浆GABA平均浓度为309±79 pmol/ml（范围：179 - 498；n = 44）。脑脊液和血浆中GABA浓度之间的相关性非常差（r = 0.18；n = 44）。因此，血浆GABA不是脑脊液GABA的合适指标。
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