Schade R, Rex H, Kästner D, Sprang C, Jacob V
Pharmazie. 1980 Feb;35(2):110-3.
We examined the influence of carbon tetrachloride on the rat liver by means of some biological parameters (body mass, GPT-activity, time of hexobarbital narcosis, aminophenazone demethylation) in comparison to the relative concentration of alpha 2 AP under conditions of a long time experiment (8 weeks). The results show, that merely the alpha 2 AP is altered significant in test groups after 1 d of treatment in comparison to the other parameters. Afterwards, under lasting carbon tetrachloride influence the macroglobulin decreases below normal levels. The potential diagnostic value of the alpha 2 AP for toxicological examinations is discussed.
在为期8周的长期实验条件下，我们通过一些生物学参数（体重、GPT活性、己巴比妥麻醉时间、氨基非那宗去甲基化），并与α2AP的相对浓度进行比较，研究了四氯化碳对大鼠肝脏的影响。结果表明，与其他参数相比，仅在治疗1天后，实验组中的α2AP就发生了显著变化。此后，在四氯化碳的持续影响下，巨球蛋白降至正常水平以下。本文讨论了α2AP在毒理学检查中的潜在诊断价值。
